Poly adenosine diphosphate-ribose polymerase inhibitors, an important class of anticancer drugs, employ synthetic lethality strategy and are particularly effective against cancers with genetic ...

Regulation of cellular levels of ADP-ribose is important in preventing ... the specific substrate contacts are different. Only the diphosphate groups of the two substrates contact the same point ...

Energy is released from ATP when the end phosphate is removed. Once ATP has released energy, it becomes ADP (adenosine diphosphate), which is a low energy molecule. ADP can be recharged back into ...