POLG-related diseases disrupt the function of the mitochondria, or "powerhouses" of the cell — starving them of energy.

In eukaryotes, DNA is tightly wound into a complex called ... However, because all remodelers move nucleosomes and all such movement is ATP dependent, mobilization is most likely a property ...

ATP (adenosine triphosphate) is the energy-carrying molecule used in cells because it can release energy very quickly. Energy is released from ATP when the end phosphate is removed. Once ATP has ...

Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury.

As ABC domains are also integrated into non-transport systems, including proteins that are involved in DNA repair and chromosome maintenance, it is likely that a common set of ATP-dependent ...

A new method for mapping torsion provides insights into the ways that the genome responds to the torsion generated by RNA polymerase II.

They demonstrated that this complex cleaves DNA and covalently attaches to the ... the activity of the SPO11 complex functions independently of ATP, distinct from its ancestral enzyme ...