As trp levels increase, trp binds to trpR, causing a conformational change that allows binding to the operator and repression of gene expression. Trp therefore acts as a self-governor by ...

How does a gene ... It turns out that the regulation of such genes differs between prokaryotes and eukaryotes. For prokaryotes, most regulatory proteins are negative and therefore turn genes ...

An elegant screening strategy unveils a molecular actor that connects widespread changes in mRNA processing with a nutrient-sensing protein modification.

Life depends on genes being switched on and off at exactly the right time. Even the simplest living organisms do this, but usually over short distances across the DNA sequence, with the on/off switch ...