After Elizabeth takes “the substance,” Sue ... including her memorable workout to a cover of DJ Endor’s “Pump It Up!” — were “brutal,” according to Qualley. In the USA Today ...

When Sue becomes greedy with her time, exceeding seven days on the outside, Elisabeth suffers the consequences, and things take a dark and twisted turn. So, how did The Substance end? Here’s ...

Battling with crippling Hollywood ageism, she's introduced to a new drug known as "the Substance." A single injection is all it takes for Elisabeth to be reborn as the beautiful and youthful Sue ...

(CNN) — “The Substance ... to kill Sue for the irreversible damage her younger double has done to her older body but can’t bring herself to finish the job. So Sue wakes up, and the ...